/* Layout: a header band, then a two-column workspace (enzyme browser | structure and sequence).
   Under 700px the columns stack. Light theme only, by choice: the 3D viewer draws on white. */
:root {
  color-scheme: light;
  --ink: #183942;
  --muted: #576c72;
  --line: #d6e0df;
  --accent: #136f70;
  --paper: #ffffff;
  --wash: #f3f7f6;
  --band: #143c44;
  --band-ink: #ffffff;
  --band-muted: #c5dfe0;
  --band-hover: #1e4f58;
  --field-line: #adbfbe;
  --hover: #eff6f5;
  --current: #dbedeb;
  --tag-bg: #e2efe9;
  --tag-ink: #1f5c45;
  --warn-bg: #fff3ed;
  --warn-ink: #8b3212;
  --warn-line: #efc4b2;
  --outline: #172b37;
  --focus: #dc7a27;
  --score-low: #edf4f5;
  --score-high: #b12a1b;
  --overlay: rgba(255, 255, 255, 0.94);
  --font: system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  --mono: ui-monospace, SFMono-Regular, Consolas, monospace;
}

* { box-sizing: border-box; }
[hidden] { display: none !important; }
body { margin: 0; background: var(--wash); color: var(--ink); font: 15px/1.5 var(--font); }
a { color: var(--accent); }
h1, h2 { text-wrap: balance; }
h2 { font-size: 24px; margin: 0 0 2px; }
h3 { font-size: 15px; margin: 0; }
p { margin: 5px 0 12px; }
label { display: block; font-size: 12px; font-weight: 650; margin-bottom: 5px; }
label.check { display: flex; align-items: center; gap: 6px; font-weight: 500; cursor: pointer; }
input[type=search], select {
  width: 100%; background: var(--paper); border: 1px solid var(--field-line); color: var(--ink);
  border-radius: 6px; padding: 9px; font: inherit; font-size: 13px;
}
input[type=range] { width: 100%; accent-color: var(--accent); }
input[type=checkbox] { accent-color: var(--accent); margin: 0; }
button { cursor: pointer; color: inherit; font: inherit; }
select:disabled, input:disabled { opacity: 0.6; }
label:has(input:disabled) { opacity: 0.5; }
button:focus-visible, input:focus-visible, select:focus-visible, a:focus-visible { outline: 3px solid var(--focus); outline-offset: 2px; }
.muted { font-size: 12px; color: var(--muted); }

.site-header {
  background: var(--band); color: var(--band-ink); padding-block: 22px;
  padding-left: max(16px, env(safe-area-inset-left, 0px));
  padding-right: max(16px, env(safe-area-inset-right, 0px));
}
.site-header-inner {
  max-width: 1700px; margin: 0 auto; padding-inline: 14px;
  display: flex; align-items: center; justify-content: space-between; gap: 24px;
}
.site-title { min-width: 0; }
.site-title h1 { font-size: 24px; line-height: 1.25; margin: 0 0 6px; }
.site-title p { margin: 0; max-width: 72ch; color: var(--band-muted); font-size: 14px; }
.site-links { display: flex; gap: 10px; flex-shrink: 0; }
.site-links a {
  color: var(--band-ink); text-decoration: none; border: 1px solid var(--band-muted);
  border-radius: 6px; padding: 6px 16px; font-size: 13px; font-weight: 600;
}
.site-links a:hover { background: var(--band-hover); }

.workspace { display: grid; grid-template-columns: 290px minmax(0, 1fr); max-width: 1700px; margin: 0 auto; }
aside {
  background: var(--paper); border-right: 1px solid var(--line);
  position: sticky; top: 0; height: 100vh; min-height: 520px; display: flex; flex-direction: column;
}
.browser-controls { padding: 20px 18px 8px; }
.browser-controls label { margin-top: 10px; }
.browser-controls label.check { margin-top: 12px; font-size: 13px; }
#count { margin: 12px 0 4px; }
#protein-list { overflow: auto; flex: 1; padding: 0 8px 8px; }
.protein-button {
  display: block; width: 100%; text-align: left; border: 0; border-radius: 6px;
  background: transparent; padding: 10px 12px; margin-bottom: 2px;
}
.protein-button:hover { background: var(--hover); }
.protein-button[aria-current=true] { background: var(--current); box-shadow: inset 3px 0 var(--accent); }
.protein-id { display: flex; align-items: center; gap: 8px; font-weight: 700; font-size: 14px; }
.protein-name { display: block; color: var(--muted); font-size: 12px; white-space: nowrap; overflow: hidden; text-overflow: ellipsis; }
.protein-stat { font-size: 11px; color: var(--muted); font-variant-numeric: tabular-nums; }
.empty { padding: 8px 12px; }
.tag {
  display: inline-block; background: var(--tag-bg); color: var(--tag-ink); border-radius: 999px;
  padding: 1px 9px; font-size: 11px; font-weight: 600; white-space: nowrap;
}
.protein-id .tag { font-size: 10px; padding: 0 7px; }

main { min-width: 0; padding: 24px 28px; }
.protein-header { display: flex; justify-content: space-between; align-items: flex-start; gap: 20px; min-height: 80px; }
.protein-heading { min-width: 0; }
.protein-heading p { margin: 0 0 6px; }
.metrics { display: flex; gap: 10px; flex-shrink: 0; }
.metric {
  padding: 10px 12px; background: var(--paper); border: 1px solid var(--line); border-radius: 7px;
  text-align: right; min-width: 92px; font-variant-numeric: tabular-nums;
}
.metric span { display: block; font-size: 10px; color: var(--muted); }
.metric strong { font-size: 20px; font-weight: 600; }
#status { font-size: 12px; color: var(--muted); min-height: 18px; margin: 4px 0 6px; }
.controls {
  display: grid; grid-template-columns: 1.3fr 1fr 1.3fr 1.2fr; gap: 18px; align-items: center;
  background: var(--paper); padding: 16px; border: 1px solid var(--line); border-bottom: 0; border-radius: 8px 8px 0 0;
}
.checkbox { display: flex; flex-wrap: wrap; align-items: center; gap: 8px 14px; }
.checkbox label { margin: 0; font-size: 12px; }
.checkbox button { font-size: 12px; border: 1px solid var(--line); border-radius: 4px; background: var(--paper); padding: 4px 10px; }
.structure-panel { position: relative; height: min(53vh, 580px); min-height: 340px; border: 1px solid var(--line); background: var(--paper); }
#viewer { position: absolute; inset: 0; }
.structure-help {
  position: absolute; bottom: 10px; left: 12px; font-size: 10px; color: var(--muted);
  background: var(--overlay); padding: 3px 7px; pointer-events: none;
}
#structure-error {
  position: absolute; top: 20px; left: 20px; right: 20px; padding: 12px 15px; border-radius: 6px;
  background: var(--warn-bg); color: var(--warn-ink); border: 1px solid var(--warn-line); font-size: 13px;
}
.legend { display: flex; flex-wrap: wrap; align-items: center; gap: 6px 15px; padding: 12px 2px 2px; font-size: 12px; color: var(--muted); }
.legend-item { display: inline-flex; align-items: center; gap: 5px; }
.swatch { width: 11px; height: 11px; border-radius: 3px; display: inline-block; }
.gradient { width: 80px; height: 9px; background: linear-gradient(to right, var(--score-low), var(--score-high)); border-radius: 3px; }
.reading-note { font-size: 12px; color: var(--muted); margin: 7px 0 16px; }
.sequence-panel { background: var(--paper); border: 1px solid var(--line); border-radius: 8px; padding: 16px; }
.sequence-heading { display: flex; justify-content: space-between; gap: 15px; align-items: baseline; margin-bottom: 5px; }
#coverage { color: var(--muted); font-size: 11px; font-variant-numeric: tabular-nums; }
#sequence { max-height: 180px; overflow: auto; display: flex; flex-wrap: wrap; align-content: flex-start; gap: 2px; padding: 8px 0; }
.residue {
  font: 13px/1.6 var(--mono); border: 1px solid transparent; border-radius: 2px;
  width: 19px; min-height: 25px; text-align: center; padding: 0; color: var(--ink);
}
.residue.cat { text-decoration: underline; text-underline-offset: 3px; font-weight: 800; }
.residue:hover, .residue.selected { border-color: var(--outline); outline: 1px solid var(--outline); }
.residue-gap { width: 4px; }
#residue-detail { font-size: 12px; color: var(--muted); margin: 10px 0 0; }
footer { font-size: 12px; color: var(--muted); margin: 17px 0; max-width: 90ch; }
footer p { margin: 0 0 6px; }
footer .credits { font-size: 11px; }

@media (max-width: 1100px) {
  .workspace { grid-template-columns: 240px minmax(0, 1fr); }
  main { padding: 20px; }
  .protein-header { display: block; }
  .metrics { margin: 12px 0; }
  .controls { grid-template-columns: 1fr 1fr; }
}

@media (max-width: 700px) {
  .site-header { padding-block: 18px; }
  .site-header-inner { display: block; padding-inline: 0; }
  .site-title p { font-size: 13px; }
  .site-links { margin-top: 12px; }
  .workspace { display: block; }
  aside { height: auto; min-height: 0; position: static; border-right: 0; border-bottom: 1px solid var(--line); }
  .browser-controls {
    display: grid; grid-template-columns: 1fr 1fr; gap: 4px 10px; padding-block: 12px;
    padding-left: max(16px, env(safe-area-inset-left, 0px)); padding-right: max(16px, env(safe-area-inset-right, 0px));
  }
  .browser-controls label[for=search] { grid-column: 1; grid-row: 1; margin-top: 0; }
  .browser-controls label[for=sort] { grid-column: 2; grid-row: 1; margin-top: 0; }
  #search { grid-column: 1; grid-row: 2; }
  #sort { grid-column: 2; grid-row: 2; }
  .browser-controls label.check { grid-column: 1 / 3; grid-row: 3; }
  #count { grid-column: 1 / 3; grid-row: 4; margin: 0; }
  #protein-list {
    display: flex; max-height: 132px; padding-block: 0 8px;
    padding-left: max(8px, env(safe-area-inset-left, 0px)); padding-right: max(8px, env(safe-area-inset-right, 0px));
  }
  .protein-button { min-width: 190px; width: 190px; }
  main { padding-block: 16px; padding-left: max(16px, env(safe-area-inset-left, 0px)); padding-right: max(16px, env(safe-area-inset-right, 0px)); }
  .metrics { gap: 7px; }
  .metric { min-width: 0; flex: 1; }
  .metric strong { font-size: 18px; }
  .controls { gap: 12px; }
  .structure-panel { height: 400px; }
  .sequence-heading { display: block; }
}

@media (prefers-reduced-motion: reduce) {
  * { scroll-behavior: auto !important; transition: none !important; }
}